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14th December 2017 @ 15:03

VTM012.jpg

VTM012                                                                                                      17/11/2017

VTM010 (0.05 g, 0.12 mmol) was dissolved in degassed toluene (2 mL). Piperidine (0.025 g, 0.29 mmol), NaOtBu (0.016 g, 0.168 mmol), JohnPhos (1.6 mg, 5.4 μmol) and Pd 2 (dba) 2 (0.3 mg, 0.6 μmol) were added to the solution and stirred at 100°C for two weeks. The reaction was quenched with 2M HCl and the organic layer extracted (EtOAc 3x2 mL). The crude was concentrated under reduced pressure and purified via column chromatography (100% EtOAc).

VTM012 COLUMN.jpeg
Attached Files
VTM012.jpg
VTM012 COLUMN.jpeg