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14th December 2017 @ 10:41

VTM011.jpg

VTM011                                                                                                    17/11/2017

 

VTM010 (0.05 g, 0.12 mmol) was dissolved in degassed toluene (2 mL). Pyrrolidine (0.02 g, 0.288 mmol), NaO t Bu (0.016 g, 0.168 mmol), JohnPhos (1.6 mg, 5.4 μmol) and Pd 2 (dba) 2 (0.3 mg, 0.6 μmol) were mixed in this order and stirred for two weeks at 100°C. The reaction was quenched (2M HCl). The organic layer was extracted (3x2mL EtOAc). The crude was concentrated in vacuo and purified via column chromatography (EtOAc).

VTM011COLUMN.jpg

NMR analysis suggested that a final product was not formed.

Attached Files
VTM011.jpg
VTM011COLUMN.jpg