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14th December 2017 @ 10:07

VTM010.jpg

 VTM010                                                                                                    07/11/2017

VTM009 (0.738 g, 1.22 mmol) was added to a solution of 3,4-difluorophenyl-1-ol (0.60 g, 4.16 mmol) in dry THF (30 mL). The mixture was cooled down to 0°C and NaH (60%, 0.17 g, 6.93 mmol)was added. The mixture was stirred at room temperature for 2 hours. The reaction was quenched with HCl (30mL) and the organic layer extracted with EtOAc (3x30 mL) and 2M HCl (3x10 mL). The crude was concentrated under reduced pressure

VTM010 CRUDE (2).jpg

and purified via column chromatography (100% EtOAc) to yield the final product (0.50 g, 48%) as a beige solid.

VTM010 PRODUCT (3).jpg
Attached Files
VTM010.jpg
VTM010 CRUDE (2).jpg
VTM010 PRODUCT (3).jpg