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1st November 2017 @ 13:45

VTM005

23/10/2017

VTM005.jpg

VTM004 (0.037 g, 0.08 mmol) was dissolved in toluene (2 mL). Pyrrolidine (0.007 g, 0.96 mmol), NaO t Bu (0.011 g, 0.11 mmol), BINAP (0.37 mg, 0.6 µmol) and Pd 2 (dpa) 3 (0.7 mg, 0.8 µmol) were added in this order to the solution and the mixture was heated at 80 °C for 16 hours. TLC analysis showed the presence of large quantities of the starting material.

VTM005 TLC 16hours.jpg

The temperature was increased to 100 °C and the reaction left to stir for two weeks. NMR analysis showed no formation of the final product.

Attached Files
VTM005.jpg
VTM005 TLC 16hours.jpg