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1st November 2017 @ 12:06

VTM004

17/10/2017

VTM004.jpg

 

VTM001 (0.31 g, 2.15 mmol) was dissolved in dry THF (10 mL) and mixed with VTM003 (0.40 g, 1.29 mmol). 60 % NaH (0.08 g, 2.15 mmol) was added and the mixture was stirred at room temperature for 3 hours. The reaction was quenched with 2M HCl (~ 30 mL). The organic layer was extracted (2M HCl 2x20 mL and EtOAc 3x20 mL), dried (MgSO4) and concentrated under reduced pressure. The crude was purified via column chromatography (50% - 80 % EtOAc in petroleum ether) to afford the final product (0.250 g, 45 %) as a yellow solid.

1HNMR VTM004.jpg

20171101_131813.jpg
Attached Files
VTM004.jpg
1HNMR VTM004.jpg
20171101_131813.jpg