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17th October 2017 @ 10:13
VTM003                                                                                                                                                                 10/10/2017 [data]21142[/data] VTM002 (1.49g, 4.78mmol) was dissolved in DCM (40mL). BAIB (1.644g, 5.10mmol) was cautiously added to the solution and the reaction was stirred over 5 days at room temperature. The reaction was quenched with aqueous saturated NaHCO3 (30mL) and the organic layer extracted ( CH2Cl2 3 x 30mL; brine 3x20mL). The crude was concentrated under reduced pressure to give a light brown powder. [data]21146[/data][data]21148[/data][data]21150[/data][data]21152[/data] The crude reaction mixture was purified via column chromatography (40% to 70% EtOAc in Petroleum Ether) to afford the product (0.40g, 27%) as a brown solid. [data]21154[/data][data]21202[/data] [data]21198[/data][data]21200[/data]
Attached Files
VTM003.jpg
VTM003CRUDE.jpg
VTM003 CRUDE2.jpg
VTM003 tlc.jpg
VTM003 TLC2.jpg
VTM003column.jpg
VTM003product.jpg
VTM003product2.jpg
VTM003columntlc.jpg