All Notebooks | Help | Support | About
17th April 2019 @ 09:42

2-chloro-6-(2-hydrazinyl)(4-chlorobenzylidene)pyrazine was synthesised from 2-chloro-6-hydrazinopyrazine and 4-chlorobenzaldehyde, as an intermediate in the synthesis of 2-chloro-3-(4-chlorophenyl)-[1,2,4]triazolo[4,3-a]pyrazine

Reaction scheme

Reaction 1 scheme.png

Risk Assessment

4chlorobenzaldehyde reaction1 risk assessment.pdf

Reagents

                                                     mass/g           moles/mmol         equivalents

2-chloro-6-hydrazinopyrazine           0.049              0.339                   1.0

4-chlorobenzaldehyde                      0.056             0.364                    1.1

Proceedure

A round bottomed flask was charged with 2-chloro-6-hydrazinopyrazine (0.0490 g, 0.339 mmol), 4-chlorobenzaldehyde (0.0560 g, 0.399 mmol) and ethanol (20 mL) in. The resulting solution was heated under reflux and monitored using TLC (3: 7 ethyl acetate: light petroleum ether solvent used) until completion (Rf = 0.35). The resulting product was then isolated and dried via vacuum filtration yielding a light yellow powder (0.0436g, 44.5%). The product was characterised via 1H and 13C NMR, infrared and melting point analysis. 

Analytical data

4chlorobenzaldehyde reaction1 C NMR spectrum.pdf

4chlorobenzaldehyde reaction1 Mass spectrum.pdf

4chlorobenzaldehyde reaction1 H NMR spectrum.pdf

Mpt = 215 - 225C

InChl Key

2-chloro-6-hydrazinopyrazine  FEDQSVIJHNBUHH-UHFFFAOYSA-N

4-chlorobenzaldehyde  AVPYQKSLYISFPO-UHFFFAOYSA-N

2-chloro-6-(2-hydrazinyl)(4-chlorobenzylidene)pyrazine  IREXIIXDQDGVMX-UHFFFAOYSA-N

Attached Files
4chlorobenzaldehyde reaction1 risk assessment.pdf
4chlorobenzaldehyde reaction1 C NMR spectrum.pdf
4chlorobenzaldehyde reaction1 Mass spectrum.pdf
4chlorobenzaldehyde reaction1 H NMR spectrum.pdf
Reaction 1 scheme.png