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16th April 2019 @ 15:19

Gastric Acid Stability Test on 5-chloro-3-(2,4-dimethoxyphenyl)-[1,2,4]triazolo[4,3-a]pyrazine

5-chloro-3-(2,4-dimethoxyphenyl)-[1,2,4]triazolo[4,3-a]pyrazine was added to a gastric acid mimic to test its stability.

Risk Assessment:

Procedure:

Stomach acid risk assessment.pdf

A 50 mL standard solution of DCl (0.075 mL, 7 mol dm-3, 0.525 mmol) and KCl (0.1863 g, 2.50 mmol) was made up with D2O. This solution was tested using Litmus paper to ensure that is was approximately pH 2. Each pyrazine product was added to the solution (ca. 2 mL), and a 1H NMR was instantly taken.

Analytical Data: 

Run 1: 

P5 Acid Test run 1.pdf

Run 2:

P5 Acid Test run 1.pdf

Write up:

This product was partially soluble in solution. Run 1 was taken 5 minutes after adding the product to the solution and run 2 was taken 3 hours afterwards. As shown by there being no change in the 1H NMRs, the product remained undegraded.

InChI Key: 

5-chloro-3-(2,4-dimethoxyphenyl)-[1,2,4]triazolo[4,3-a]pyrazine: LPODABXRBQELBM-UHFFFAOYSA-N

Attached Files
P5 Acid Test run 1.pdf
P5 Acid Test run 2.pdf
Stomach acid risk assessment.pdf