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16th April 2019 @ 15:12

Gastric Acid Stability Test on 5-chloro-3-(3-nitrophenyl)-[1,2,4]triazolo[4,3-a]pyrazine

5-chloro-3-(3-nitrophenyl)-[1,2,4]triazolo[4,3-a]pyrazine was added to a gastric acid mimic to test its stability.

Risk Assessment: 

Stomach acid risk assessment.pdf

Procedure:

A 50 mL standard solution of DCl (0.075 mL, 7 mol dm-3, 0.525 mmol) and KCl (0.1863 g, 2.50 mmol) was made up with D2O. This solution was tested using Litmus paper to ensure that is was approximately pH 2. Each pyrazine product was added to the solution (ca. 2 mL), and a 1H NMR was instantly taken.

Analytical Data: 

P3 Acid Test.pdf

Write up:

This product did not dissolve in the solution. Further experiments should be completed to test the products stability in solution more similar to the bile.

InChI Key:

5-chloro-3-(3-nitrophenyl)-[1,2,4]triazolo[4,3-a]pyrazine: WCCGFMGKEGZANC-UHFFFAOYSA-N

Attached Files
P3 Acid Test.pdf
Stomach acid risk assessment.pdf