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22nd March 2018 @ 14:49

Method:

2-chloro-6-hydrazinopyrazine (A) (100.00 mg, 0.70 mmol, 1.00 equiv.) was dissolved in EtOH (10 mL) forming a bright yellow solution, to which 4 bromobenzaldehyde (B) (141 mg, 0.76 mmol, 1.1 equiv.) was added. The reaction was stirred for a further 3.5 hours and was monitored by TLC. During this time, a yellow precipitate formed. The reaction mixture was filtered under vacuum to give 2-chloro-6-(2-hydrazinyl(4-bromobenzylidene))pyrazine) as a yellow powder (111.3 mg, 51.6%) which was characterised by IR and 1H NMR.TLC of the showed the reaction had gone to completion.


Attached Files
22:3-1.png
4-bromo hydrazone formation 1H NMR.pdf