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20th March 2018 @ 14:13

2,6-Dichloropyrazine (3 g, 20.1 mmol) was vigorously stirred in ethanol (30 mL) and hydrazine hydrate (1 mL, 1.02 g, 20.1 mmol) was added. The resulting mixture was heated at reflux (78 ˚C) overnight (~16 hours), forming a yellow solution. After completion (monitored by TLC, 30% EtOAc in Hexane, Rf = 0.2), a yellow solid precipitated out of solution, and was filtered and dried, yielding fine, yellow crystals of 2-Chloro- 6-hydrazinopyrazine (0.189g, 6.7%). The filtrate was also recovered in vacuo to give a yellow powder (2.001g, 70.96%). Both of these products were characterised by 1H NMR and IR.

Attached Files
20:3-4.png
2-chloro-6-hydrazinopyrazine.png
H1 NMR of 2-chloro-6-hydrazinylpyrazine.pdf