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6th March 2018 @ 16:20

Method:

2-chloro-6-hydrazinopyrazine (A) (100.7 mg, 0.70 mmol, 1.00 equiv.) was partially dissolved in EtOH (10 mL) after it was diluted by a factor of 10, forming a white solution. Benzaldehyde (B) (81.0 mg, 0.77 mmol, 1.1 equiv.) was then added causing full dissolution. The solution was stirred for five minutes at room temperature before a solid precipitated out of the reaction mixture. The reaction was stirred for a further 2.5 hours with no significant change in colour observed; it was monitored by TLC (1:9 Ethyl acetate : PET ether for half the reaction and  3:7 Ethyl acetate : PET ether for the other half) until completion. The solid was filtered under vacuum to give 2-chloro-6-(2-hydrazinyl(benzylidene)pyrazine) as a white powder (71.3 mg,44.5%). This was characterised by IR and 1HNMR. 

 

 

Attached Files
miniproject2.jpg
Unsubstituted hydrazone 1H NMR.pdf