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6th October 2016 @ 03:16

 

AEW 319-1 (155 mg, 0.90 mmol, 1.0 equiv.) was dissolved in CH2Cl2 (1 mL) and a drop of AcOH was added. Dimethylamine (0.18 mL, 1.0 equiv., 33% in abs ethanol) was added and the reaction mixture stirred at rt for 15 mins (yellow to orange soln).

NaCNBH3 (86 mg, 0.45 mmol, 0.5 equiv.) was added in a single portion at rt and the reaction mixture stirred at rt for...

 

Hazard Identification Risk Assessment and Controls

HIRAC AEW 320-1.doc
HIRAC AEW 320-1.pdf

Strings

FC1=C(F)C=C(C(CO)=O)C=C1

to

FC1=C(F)C=C(C(N(C)C)CO)C=C1

 

InChI=1S/C8H6F2O2/c9-6-2-1-5(3-7(6)10)8(12)4-11/h1-3,11H,4H2

to

InChI=1S/C10H13F2NO/c1-13(2)10(6-14)7-3-4-8(11)9(12)5-7/h3-5,10,14H,6H2,1-2H3

Attached Files
6th October 2016 @ 03:13

Procedure


Strings

FC1=C(F)C=C(C(OC)(OC)CO)C=C1

to

FC1=C(F)C=C(C(CO)=O)C=C1

 

InChI=1S/C10H12F2O3/c1-14-10(6-13,15-2)7-3-4-8(11)9(12)5-7/h3-5,13H,6H2,1-2H3

to

InChI=1S/C8H6F2O2/c9-6-2-1-5(3-7(6)10)8(12)4-11/h1-3,11H,4H2

Attached Files