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3rd February 2014 @ 21:16

Scale up of Synthesis of methyl 2-(3,4-difluorophenyl)-2-((tetrahydro-2H-pyran-2-yl)oxy)acetate (AEW 109-1)

Procedure:

AEW 103-3 (440 mg, 2.18 mmol) was dissolved in anhydrous CH2Cl2 (5 mL) and pTsOH (75 mg, 0.44 mmol, 0.2 equiv) was added followed by 3,4-dihydro-2H-pyran (0.20 mL, 2.39 mmol, 1.1 equiv) and the reaction mixture was stirred at room temperature for 1 h.


Data:

 

Hazard and Risk Assessment:

HIRAC AEW 109-1.pdf

InChi:

InChI=1S/C9H8F2O3/c1-14-9(13)8(12)5-2-3-6(10)7(11)4-5/h2-4,8,12H,1H3

to

InChI=1S/C14H16F2O4/c1-18-14(17)13(20-12-4-2-3-7-19-12)9-5-6-10(15)11(16)8-9/h5-6,8,12-13H,2-4,7H2,1H3

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