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Repeat of Synthesis of 2-Chloro-6-hydrazinylpyrazine (AEW 85-1), see also Synthesis of 2-Chloro-6-hydrazinylpyrazine (AEW 85-2)
Started 8.30 am
2,6-Dichloropyrazine (4 g, 27.0 mmol) was vigorously stirred in ethanol (40 mL) and hydrazine hydrate (1.32 mL, 1.36 g, 27.0 mmol) was added. The resulting mixture was heated at 80 ˚C for 12 h. Reaction incomplete. Stirred overnight and still SM. Stirred over the weekend..with a TLC check...couldn't see SM. Solvent evaporated - still SM by NMR. Resubmitted to the reaction conditions.
Data:
1H NMR (200 MHz, CDCl3): incomplete
1H NMR (300 MHz, CDCl3):
Hazard and Risk Assessment:
See Synthesis of 2-Chloro-6-hydrazinylpyrazine (AEW 85-1)
InChi Strings:
InChI=1S/C4H2Cl2N2/c5-3-1-7-2-4(6)8-3/h1-2H
to
InChI=1S/C4H5ClN4/c5-3-1-7-2-4(8-3)9-6/h1-2H,6H2,(H,8,9)
Uri:https://malaria.ourexperiment.org/uri/447
Key:2166f33ff8cba72da24e468f4cacf450
Last Updated:20th November 2013 @ 05:42