All Notebooks | Help | Support | About
21st February 2017 @ 02:23

See EGT 163-1

 


Outcome


Rationale

Attempt to esterify the acid to the ethyl ester.

Procedure

3,4-difluorophenylacetic acid (10.0 g, 58.1 mmol, 1 equiv.) and p-TsOH (100 mg, 0.581 mmol, 0.01 equiv.) were dissolved in EtOH (132 mL) and the reaction heated to reflux (80 oC). The reaction was cooled to rt and the solvent removed to give AEW 324-1 as a clear pale yellow oil 

Notes

Theoretical yield = 11.63 g

w/prod = 

Ref: WO 1999008697 A1

 

HIRAC

 

AEW 324-1.doc
AEW 324-1.pdf

Strings

OC(CC1=CC(F)=C(F)C=C1)=O

to

O=C(OCC)CC1=CC(F)=C(F)C=C1

InChI=1S/C8H6F2O2/c9-6-2-1-5(3-7(6)10)4-8(11)12/h1-3H,4H2,(H,11,12)

to

InChI=1S/C10H10F2O2/c1-2-14-10(13)6-7-3-4-8(11)9(12)5-7/h3-5H,2,6H2,1H3

Attached Files
AEW 324-1.rxn
AEW 324-1.png
AEW 324-1.cdxml
AEW 324-1.doc
AEW 324-1.pdf