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24th August 2016 @ 01:49

Procedure

The ratio between the reactants in this flask was as follows:50mg of 3-bromo-5-chloro-[1,2,4]triazolo[4,3-a]pyrazine(214µmol,1equiv.),6.16mg of Pd(dba)2(21.42µmol, 0.05equiv.), 33.21mg of Pd(dba)2(10.71µmol, 0.05equiv.) 36.90mg of piperazine (428.35µmol, 1.2equiv),30.87mg of t-BuONa(642.53µmol, 1.5equiv.),4.47mg of JohnPhos(14.99µmol,0.07equiv.) The reactants were placed in the flask and purged with argon then 2ml of toluene was added.The mixture was purged with argon again and stirred under argon at room temperature.The reaction will be monitored by TLC

 

HIRAC

HM 6-3.docx


Log

24th Aug

The reaction started at 3:10pm.After an hour, the reaction had gone completion.

TLC was perfomed(25%EtOAc in petroleum)

It looked like ,the product could be the base line spot


Attached Files
HM 6-3.png
HM 6-3.docx
IMG_2941.JPG
Comments
Re: Synthesis of 5-chloro-3-(piperazin-1-yl)-[1,2,4]triazolo[4,3-a]pyrazine (HM 6-3) by Mandrake Fernflower
25th August 2016 @ 16:01
Part of me wonders if side reactions are to blame. Might want to try air stable phos and 1-BOC-piperazine ??

Looks like the reaction completed. Nice work!