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23rd August 2016 @ 09:55

For Wed 24th August


Procedure

KOH (160 mg, 2.85 mmol, 1.5 equiv.) was dissolved in DMF (6 mL) at 120 ˚C and dimethylamine (191 uL, 128 mg, 3.71 mmol, 1.5 equiv.) was added to the resulting solution.

After 30 min, a solution of AEW 308-1 (~1.9 mmol, 1 equiv.) in DMF (6 mL) was added.

After completion, the reaction was cooled to rt, diluted with water (30 mL) and extracted with Et2O (4 x). The combined organic layers were washed with water (3 x), brine (3 x), dried (MgSO4), filtered and concentrated under reduced pressure to give the crude product as 


Strings

InChI=1S/C10H10F2O5S/c1-16-10(13)9(17-18(2,14)15)6-3-4-7(11)8(12)5-6/h3-5,9H,1-2H3

to

InChI=1S/C11H13F2NO2/c1-14(2)10(11(15)16-3)7-4-5-8(12)9(13)6-7/h4-6,10H,1-3H3

 

O=C(OC)C(OS(C)(=O)=O)C1=CC(F)=C(F)C=C1

to

O=C(OC)C(N(C)C)C1=CC(F)=C(F)C=C1

 

 

 

Reference

Ref: 10.1055/s-2006-942488

Attached Files
AEW 310-1.png
AEW 310-1.cdxml