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10th August 2016 @ 02:38

 

Crude AEW 303-1 (566 mg, 2.01 mmol, 1 equiv.) was suspended in EtOH (20 mL) and  4-(difluoromethoxy)benzaldehyde (0.27 mL, 2.01 mmol, 1 equiv.) was added to the reaction mixture. The reaction was stirred at rt overnight. A bright yellow suspension was formed, solvent was removed in vacuo and the crude yellow product dried further at the high vac (quantitive yield). Used directly as crude in next step: Synthesis of 3-(4-(difluoromethoxy)phenyl)-N-(2-(trifluoromethyl)pyridin-4-yl)-[1,2,4]triazolo[4,3-a]pyrazine-5-carboxamide (AEW 300-1).


Data:

 

Hazard and Risk Assessment:


Strings:

O=C(NC1=CC=C(F)C(Cl)=C1)C2=NC(NN)=CN=C2

to

O=C(NC1=CC=C(F)C(Cl)=C1)C2=NC(N/N=C/C3=CC=C(OC(F)F)C=C3)=CN=C2

InChI=1S/C11H9ClFN5O/c12-7-3-6(1-2-8(7)13)16-11(19)9-4-15-5-10(17-9)18-14/h1-5H,14H2,(H,16,19)(H,17,18)

to

InChI=1S/C19H13ClF3N5O2/c20-14-7-12(3-6-15(14)21)26-18(29)16-9-24-10-17(27-16)28-25-8-11-1-4-13(5-2-11)30-19(22)23/h1-10,19H,(H,26,29)(H,27,28)/b25-8+


Attached Files
AEW 305-1.png
AEW 305-1.cdxml