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3rd August 2016 @ 05:19

Scaled up for the synthesis of left-hand side chain of some 'Frontrunner Molecules"

GitHub Issue #400

Outcome


Procedure


AEW 301-1 crude (~18.9 mmmol, 1 equiv.) was dissolved in EtOH (200 mL) and hydrazine hydrate (1.84 mL, 37.8 mmol, 2 equiv.) was added and the reaction mixture stirred at 80 ˚C overnight.

 

Data:

 

Hazard and Risk Assessment:

See here 

 

Strings

InChI=1S/C11H6Cl2FN3O/c12-7-3-6(1-2-8(7)14)16-11(18)9-4-15-5-10(13)17-9/h1-5H,(H,16,18)

to

InChI=1S/C11H9ClFN5O/c12-7-3-6(1-2-8(7)13)16-11(19)9-4-15-5-10(17-9)18-14/h1-5H,14H2,(H,16,19)(H,17,18)

 

ClC1=CN=CC(C(NC2=CC=C(F)C(Cl)=C2)=O)=N1

to

O=C(NC1=CC=C(F)C(Cl)=C1)C2=NC(NN)=CN=C2

Attached Files
AEW 303-1.cdxml
AEW 303-1.png