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27th July 2016 @ 01:44

requires HRMS, IR and 19F NMR 

Crude AEW 102-11 was dissolved in MeOH (20 mL) and a few drops of H2SO4 was added and the reaction mixture stirred at 80 ˚C for 16 hours.

 Poured over water (40 mL) and extracted into EtOAc (30 mL x3). Combined organic layers were dried over MgSO4, filtered and evaporated to give a yellow oil. Crude material was filtered by flash column chromatography over silica (10% EtOAc in Petrol to EtOAc) to give a yellow oil (x g, x mmol, x% yield over three steps).



TLC (30% EtOAc in hexane)


Ref NMR from CRO:

Methyl ESTER NMR.pdf


Hazard and Risk Assessment:

HIRAC AEW 103-1.pdf







Possible useful paper for chiral HPLC of enantioenriched compounds: JACS, 2002, 124, 2870 (