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24th November 2014 @ 06:24
2-Chloro-6-hydrazinylpyrazine (from [blog=11147]Synthesis of 2-Chloro-6-hydrazinylpyrazine (AEW 85-4)[/blog]): 8.00 g, 55.3 mmol) was dissolved in toluene (150 mL), triethyl orthoformate (18.3 ml, 110 mmol, 2 eq) and TsOH (500 mg, 2.76 mmol, 10 mol %) added, and the reaction mixture refluxed (bath temp 110 oC) for 24 h.  Hazard and Risk Assessment: See Synthesis of 5-chloro-[1,2,4]triazolo[4,3-a]pyrazine (TM 37-1) Strings: InChI=1S/C4H5ClN4/c5-3-1-7-2-4(8-3)9-6/h1-2H,6H2,(H,8,9) to InChI=1S/C5H3ClN4/c6-4-1-7-2-5-9-8-3-10(4)5/h1-3H NNC1=NC(Cl)=CN=C1 to ClC1=CN=CC2=NN=CN21
Attached Files
AEW 208-1.cdxml
AEW 208-1.png