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11th November 2014 @ 11:53

Reaction Scheme: 

Experimental Procedure:

see Synthesis of N-(3-chlorophenyl)-6-hydrazinylpicolinamide (JS 5-3)

 

To a solution of JS 5-3 ( 25 mg, 0.095 mmol) in MeCN (1.5 mL) was added acetic acid (1 drop). 4-(difluoromethoxy)benzaldehyde (0.0125 mL, 0.095 mmol) was then added and the reaction was allowed to stir over the weekend. TLC analysis showed that the product has been formed. The Solvents were then removed in Vacuo to yield a yellow oil that after leaving overnight crystallised to form a yellow solid. 

SMILES: 

ClC1=CC=CC(N/N=C/C2=CC=C(C#N)C=C2)=N1

to

ClC1=CC=CC2=NN=C(C3=CC=C(C#N)C=C3)N21

InchI Strings:

InChI=1S/C13H9ClN4/c14-12-2-1-3-13(17-12)18-16-9-11-6-4-10(8-15)5-7-11/h1-7,9H,(H,17,18)/b16-9+

to 

InChI=1S/C13H7ClN4/c14-11-2-1-3-12-16-17-13(18(11)12)10-6-4-9(8-15)5-7-10/h1-7H

Risk Assessment:

JS 7-1.docx
Attached Files
JS 7-1.png
JS 7-1.docx