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24th April 2014 @ 11:20

World Malaria Day is April 25th - it'd be great if you could help spread the word about malaria and the Open Source Malaria consortium. There's a Twibbon campaign at: This will overlay the OSM logo on your Twitter avatar (please save your old picture). You're meant to be able to customize the tweet you send out in support. If so:

If you're new to OSM, you could say this:

Join the network: #netacollaborator for @O_S_M on World Malaria Day to #defeatmalaria

It'd be useful to gain support from these malaria ambassadors: so if anyone knows a way to encourage them to tweet the above, that'd be great.

If you've already contributed to OSM, you could say this:

I'm a contributor to @O_S_M. I work on chemistry @SydneyUni and use #openscience to #defeatmalaria #netacollaborator

(If you find you can't customise the tweet, then maybe send out the Twibbon one, then paste a new tweet with one of the above)

Thank you all in advance for spreading the word about malaria and about OSM!

(post authored by Mat Todd)

16th April 2014 @ 11:59

Attached is the first OSM Newsletter detailing recent progress and what's currently needed. Please distribute to those you think might be interested.

First Newsletter                            Student Edition of First Newsletter

OSM Newsletter April 2014.pdf
OSM Newsletter April 2014_Student.pdf

Future editions will be written by other members of the consortium - templates will be made available as powerpoint or keynote files with slight preference for keynote where possible. Once completed, the draft should be sent to

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9th April 2014 @ 02:40

GitHub Issue #174

The team are currently in the middle of synthesising the triazolopyrazines, both ether and amide linked compounds in the series. I (Jo Ubels) have been looking at the data from MMV on the ether linked series (example below).

I have synthesised the core triazolopyrazine rings (shown in black) with the benzonitrile group attached (pink) and am synthesising more with a chloro group in place of the nitrile. I have made one complete compound with phenethyl alcohol as the ether to test the reaction conditions. My question is, what alcohols (blue), amines or thiols should we buy to link to my compounds? Looking through the MMV data I have found that most of the alcohols already used are fluorinated so I searched for alcohols/amines/thiols with other ring substituents. A selection of alcohols that I have found can be seen in this table along with prices and shipping information.

Table of possible alcohols to buy.pdf

The alcohols that have already been tested can be found in this table, along with their potency data.

Alcohols-Amines that have been tested.pdf

Which compounds should we synthesise next based on the available alcohols? Are any of the possible alcohols particularly attractive/unattractive when paired with the nitrile or chloro group containing triazolopryazine ring cores? We need to be able to reatin potency and increase the solubility and metabolic stability of the compounds. If you can help us decide what to buy and synthesise next then we'd love to hear from you. The list of alcohols/amines/thiols is not exhaustive and I will try to add more suggestions in the next day or so.

To make suggestions you can post a comment below this blog, on GitHub, our G+ site, Twitter or last (and also least) by email to


Jo & the OSM Team

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