A search for each scheme was performed using the reaction structure search and ticking the ‘substructure’ box. The reactions were filtered by:

- Yields of 70-100%
- Journals in English
- Must have an available experimental procedure.

*Promising experiments/conditions for pyrazines:*

1. 10.1021/np200386c

Yield of 94%

2. 10.1021/jm061247v

Yield of 83%

*Promising experiments/conditions for pyridines:*

3. 10.1021/jo800866w

There are several options for the alcohol here, each with different yields.

4. 10.1021/jo901707x

Yields:

90% where Ar = 2-MeO-C_{6}H_{4} and R = H

92% where Ar = 4-MeO-C_{6}H_{4} and R = H

96% where Ar = C_{6}H_{5} and R = Me

75% where Ar = 4-CF_{3}-C_{6}H_{4} and R = H

93% where Ar = 4-Cl-C_{6}H_{4} and R = H

5. 10.1021/jo0602773

Yield of 95%

I will start by trying the reaction from reference 4, but using 2,6-dichloropyrazine instead of the 2-chloropyradine as it is closer to the triazolopyrazine. I will also use phenethyl alcohol (HO(CH_{2})_{2}C_{6}H_{5}) as this is closest to the ether I will eventually use to link to the triazolopyrazine. I will also attempt this reaction using 2,6-dichloropyrazine and the 4-MeO-C_{6}H_{4} alcohol listed above as a comparison. Next week I will try the reactions from references 1 and 2 as their reaction times are longer than what I can achieve this afternoon.

A search for each scheme was performed using the reaction structure search and ticking the ‘substructure’ box. The reactions were filtered by:

- Yields of 70-100%
- Journals in English
- Must have an available experimental procedure.

*Promising experiments/conditions for pyrazines:*

1. 10.1021/np200386c

Yield of 94%

2. 10.1021/jm061247v

Yield of 83%

*Promising experiments/conditions for pyridines:*

3. 10.1021/jo800866w

There are several options for the alcohol here, each with different yields.

4. 10.1021/jo901707x

Yields:

90% where Ar = 2-MeO-C_{6}H_{4} and R = H

92% where Ar = 4-MeO-C_{6}H_{4} and R = H

96% where Ar = C_{6}H_{5} and R = Me

75% where Ar = 4-CF_{3}-C_{6}H_{4} and R = H

93% where Ar = 4-Cl-C_{6}H_{4} and R = H

5. 10.1021/jo0602773

Yield of 95%

I will start by trying the reaction from reference 4, but using 2,6-dichloropyrazine instead of the 2-chloropyradine as it is closer to the triazolopyrazine. I will also use phenethyl alcohol (HO(CH_{2})_{2}C_{6}H_{5}) as this is closest to the ether I will eventually use to link to the triazolopyrazine. I will also attempt this reaction using 2,6-dichloropyrazine and the 4-MeO-C_{6}H_{4} alcohol listed above as a comparison. Next week I will try the reactions from references 1 and 2 as their reaction times are longer than what I can achieve this afternoon.

A search for each scheme was performed using the reaction structure search and ticking the ‘substructure’ box. The reactions were filtered by:

- Yields of 70-100%
- Journals in English
- Must have an available experimental procedure.

*Promising experiments/conditions for pyrazines:*

1. 10.1021/np200386c

Yield of 94%

2. 10.1021/jm061247v

Yield of 83%

*Promising experiments/conditions for pyridines:*

3. 10.1021/jo800866w

There are several options for the alcohol here, each with different yields.

4. 10.1021/jo901707x

Yields:

90% where Ar = 2-MeO-C_{6}H_{4} and R = H

92% where Ar = 4-MeO-C_{6}H_{4} and R = H

96% where Ar = C_{6}H_{5} and R = Me

75% where Ar = 4-CF_{3}-C_{6}H_{4} and R = H

93% where Ar = 4-Cl-C_{6}H_{4} and R = H

5. 10.1021/jo0602773

Yield of 95%

I will start by trying the reaction from reference 4, but using 2,6-dichloropyrazine instead of the 2-chloropyradine as it is closer to the triazolopyrazine. I will also use phenethyl alcohol (HO(CH_{2})_{2}C_{6}H_{5}) as this is closest to the ether I will eventually use to link to the triazolopyrazine. I will also attempt this reaction using 2,6-dichloropyrazine and the 4-MeO-C_{6}H_{4} alcohol listed above as a comparison. Next week I will try the reactions from references 1 and 2 as their reaction times are longer than what I can achieve this afternoon.

- Yields of 70-100%
- Journals in English
- Must have an available experimental procedure.

*Promising experiments/conditions for pyrazines:*

1. 10.1021/np200386c

Yield of 94%

2. 10.1021/jm061247v

Yield of 83%

*Promising experiments/conditions for pyridines:*

3. 10.1021/jo800866w

There are several options for the alcohol here, each with different yields.

4. 10.1021/jo901707x

Yields:

90% where Ar = 2-MeO-C_{6}H_{4} and R = H

92% where Ar = 4-MeO-C_{6}H_{4} and R = H

96% where Ar = C_{6}H_{5} and R = Me

75% where Ar = 4-CF_{3}-C_{6}H_{4} and R = H

93% where Ar = 4-Cl-C_{6}H_{4} and R = H

5. 10.1021/jo0602773

Yield of 95%

_{2})_{2}C_{6}H_{5}) as this is closest to the ether I will eventually use to link to the triazolopyrazine. I will also attempt this reaction using 2,6-dichloropyrazine and the 4-MeO-C_{6}H_{4} alcohol listed above as a comparison. Next week I will try the reactions from references 1 and 2 as their reaction times are longer than what I can achieve this afternoon.