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8th August 2013 @ 09:02
Resynthesis of glycolic acid acetonide. See also [blog=409]Synthesis of Glycolic Acid Acetonide (PMY 7-1)[/blog]. Started 11.30 am Thursday 15th August Condensation of acetone and glycolic acid to give the protected/activated glycolic acid acetonide for further side chain elaboration. Glycolic acid (2.05 g, 27.0 mmol, 1 equiv.) was stirred in acetone (40 mL) with a few crystals of p-TSA for 1 hour. NaHCO3 (approx 1 g) was added and dried (MgSO4) before filtration and partially concentration to a colourless oil.  NMR:   References:   doi: 10.1016/j.ejmech.2008.02.022 doi: 10.1016/0040-4039(90)80091-Y Risk and Hazard AssessmentSee: [data]338[/data]
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