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6th August 2013 @ 07:42

Repeat of Hydrolysis of MD 17-1 to give 2-((1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carbonyl)oxy)propanoic acid (MD 18-1) and Hydrolysis of MD 17-1 to give 2-((1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carbonyl)oxy)propanoic acid (MD 18-3) 

N.B No TLC data but need to monitor closely to prevent hydrolysis of both ester groups

AEW 71-1 (585 mg, 1.75 mmol) was dissolved in EtOH (27 mL), 20% NaOH (2.6 mL, 9 equiv.) and the mixture was stirred at room temperature for 1.5 h. No SM present by TLC.


(452 mg, 1.38 mmol, 79% yield)


Data:

400 MHZ

AEW 73-1 nmr13C.pdf
AEW 73-1 nmr1H.pdf
AEW 73-1 paper.zip


See also:
Hydrolysis of MD 17-1 to give 2-((1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carbonyl)oxy)propanoic acid (MD 18-1) and Hydrolysis of MD 17-1 to give 2-((1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carbonyl)oxy)propanoic acid (MD 18-3) 


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Attached Files
AEW 73-1 nmr13C.pdf
AEW 73-1 nmr1H.pdf
AEW 73-1 paper.zip