All Notebooks | Help | Support | About
20th June 2013 @ 07:52

See also See Coupling of pyrrole carboxylic acid PMY 8-4 and glycinamide derivative PMY30-3 (PMY 34-1) but this method uses coupling reagents rather than acid chloride.

Procedure:

AEW 10-2 (230 mg, 1 mmol, 1 equiv), EDCI (262 mg, 1.2 mmol, 1.2 equiv.) and HOBt (14 mg, 0.1 mmol, 0.1 equiv.) were stirred in CH2Cl2 (10 mL) and stirred at room temperature for 15 minutes. AEW 64-1 crude (~1.14 mmol) was added and the reaction mixture stirred at room temperature overnight. New spot on TLC. Aqueous work-up with saturated aqueous sodium hydrogen carbonate and CH2Cl2, brine, MgSO4 filtered and evaporated. 

Column: 1-20% MeOH in DCM.

First spot - recovered starting acid 90 mg

second spot - impure final product ~20 mg. 


Data:


Hazard and Risk Assessment:


See Coupling of pyrrole carboxylic acid PMY 8-4 and glycinamide derivative PMY30-3 (PMY 34-1)

Linked Entries
This entry is linked by:
Attached Files
AEW 65-1.png
AEW 65-1 2nd spot col.zip
AEW 65-1 col.zip