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6th June 2013 @ 12:54

See also: Repeat Preparation of 1-(4-Fluoro-phenyl)-2,5-dimethyl-1H-pyrrole (AEW 1-1)

SProcedure:

4-fluoroaniline (10.4 mL, 110 mmol, 1.1 equiv.) and 2,5-hexanedione (11.7 mL, 100 mmol, 1 equiv.) were heated to 110 °C (oil bath temp.). After 13 hours, reaction was cooled to room temperature. The mixture was dissolved in hot EtOH (15 mL) and a mixture of EtOH (30 mL) and aqueous solution of 10% citric acid (15 mL). The reaction was slowly cooled to approx. 10 °C with periodic shaking. The resulting crystals were filted and washed with water (approx. 200 mL) to obtain the product as a tan crystalline solid containing dark brown solid 


Hazard and Risk Assessment:

See Repeat Preparation of 1-(4-Fluoro-phenyl)-2,5-dimethyl-1H-pyrrole (AEW 1-1)

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