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26th March 2013 @ 15:13


PT-1-11A (16.6 mg 48.8 umol), was suspended in MeOH (10 ml) and saturated aqueous ammonia (10 ml) and stirred for 30 minutes, whereupon TLC indicated completion. The reaction was concentrated in vacuo to give a solid which was purified the same way as Amidation of PT-1-9A (PT-1-10) then dried in vacuo to give a white solid PT-1-12-C1 (7 mg, 21 umol, 43%, Rf 0.55 (ethyl acetate)). 


Analysis: NMR consistent with Amidation of PT-1-9A (PT-1-10), sans N-methyl group and introduction of an N-H at 5.1 ppm, plus traces of ethyl acetate. Mass spec consistent (ESI-Nom).

ESI-Acc (Finnegan MAT-900 ESI-Positive HRMS): Expected 325.08909 (C14H16O3N3FS) Found 325.08881 (0.28 ppm)

Linked Entries
Attached Files
PT-1-12-C1 1H.pdf
PT-1-12-C1 13C.pdf
PT-1-12-C1 MS.jpg