All Notebooks | Help | Support | About
This is a previous version of this entry. To view the latest click here. or to view all revisions click here.
6th December 2012 @ 22:49
Reaction Scheme

AEW 2-1 (200 mg, 0.92 mmol, 1 equiv.) was dissolved in MeOH (15 mL). Sodium borohydride (35 mg, 0.92 mmol, 4 hydride equiv.) was added. TLC after 2 hours showed reaction complete.

Acetone (10 mL) added to the reaction mixture, stirred for 10 minutes and then concentrated under reduced pressure. Water was added to the residue and extracted with DCM (3 × 10 mL). The extracts were washed with brine then dried (MgSO4) and concentrated under reduced pressure to give a ....

Note: The product alcohol is not particularly stable, use very soon after preparation.

1H NMR Data

Risk and Hazard Assessment:
AEW 3-1.pdf