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22nd October 2012 @ 04:42
AEW%2018-1.png

Reaction start time: 3.20pm
Powdered KOH (81 mg, 1.45 mmol, 4 equiv.) was added to DMSO (0.7 mL) and stirred for 5 min. AEW 5-2 (100 mg, 0.36 mmol, 1 equiv.) was added, followed immediately by methyl iodide (23 microlitre, 0.36 mmol, 1 equiv.). After 3.5 h, the reaction mixture was poured into water (7 mL), extracted with DCM (3x 7 mL), washed with brine, dried (MgSO4), filtered and evaporated to give a clear oil. Turned cloudy on addition of CDCl3, indicating presence of DMSO..confirmed by crude NMR

TLC: (10% EtOAc in DCM):
AEW 18-1.jpg


Hazard and Risk Assessment:
AEW 18-1 HIRAC.pdf


Reference:

http://dx.doi.org/10.1016/0040-4020(79)87035-0
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AEW 18-1 HIRAC.pdf
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