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10th July 2012 @ 01:03
Starting material consumed, potential double sulfonation. === Chlorosulfonation of aryl pyrrole PMY 1-6 using chlorosulfonic acid. [b]Reaction Start Time: 9.50 10/07/12[/b] Solid PMY 1-6 (250 mg, 1.3 mmol, 1 equiv.) was mixed under an inert atmosphere at room temperature. Chlorosulfonic acid (0.5 mL, 7.5 mmol, 5.7 equiv.) was added dropwise. Slight exotherm. Reaction is a brown solution. TLC (mini work-up: a drop added to water, Et2 layer TLC'd) after
Attached Files
Scheme
Risk Assessment
TLC <5 min
TLC <5 min
TLC 2 hours at 60 celcius
1H NMR crude