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20th March 2012 @ 23:51
Product obtained in 55% crude yield used in PMY 11-6 and PMY 42-1. === Synthesis and isolation of the acid chloride of PMY 8-4 for coupling reactions. [b]Reaction start time: 10.40 21/03/12[/b] Acid JRC 2-1 (500 mg, 2.14 mmol, 1 equiv.) was stirred in dry PhMe (3 mL) and cooled in ice. Thionyl chloride (0.31 mμL, 4.29 mmol, 2 equiv.). The reaction was allowed to warm to room temperature. After 3 hours, the reaction was concentrated under reduced pressure twice from PhMe (3 mL). The residue was triturated twice with hexane (8 + 2 mL) and the filtrate concentrated under reduced pressure to obtain the acid chloride as a yellow solid (298 mg, 55%). The product was used without further purification. [b]See also:[/b] [blog]2508[/blog] [blog]1792[/blog] [blog]2051[/blog] [blog]1588[/blog] [b]Risk and Hazard Assessment:[/b] As for [blog]499[/blog].
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