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29th October 2016 @ 03:39

Scheme:

Following procedure outlined in [Synlett, Issue 18, 2823-2825, 2005, ISSN:0936-5214, DOI:10.1055/s-2005-918948]

 

Procedure:

Under inert atmosphere, step 3 product [rxn 3-2] (0.4416 g, 1.489 mmol, 1 eq) was disolved in dry benzene (10.0 mL) in a 20 mL microwave reaction vial. Phenyl acetylene (0.20 mL, 1.8 mmol, 1.2 eq) and InCl3 (33 mg, 0.15 mmol, 0.10 eq). The reaction vial was placed in a microwave synthesizer, and was heated to 100°C for 1 hour.

 

TLC:

The crude reation mixture was spotted on a TLC plate (silica gel), developed in 1:1 EtOAc/hexanes, and visualized with UV. The TLC indicated that no reaction had occured. Lanes from top to bottom are [rxn 3-2] product, phenyl acetylene, cospot, workup mixture.

Attached Files
Reaction 4-2.png