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16th May 2014 @ 02:36
Osm: OSM-S-221_to_OSM-S-230

Original Sources

Attempts:

http://malaria.ourexperiment.org/uri/558

GitHub Link

 

Biological Data

N/A

Synonyms

AEW 129

O=C1N(C(COCC2=CC=CC=C2)=O)CCO1

InChI=1S/C12H13NO4/c14-11(13-6-7-17-12(13)15)9-16-8-10-4-2-1-3-5-10/h1-5H,6-9H2

GPTTUKZPXUMFOM-UHFFFAOYSA-N

3-(2-(benzyloxy)acetyl)oxazolidin-2-one

Attached Files
16th May 2014 @ 02:28
Osm: OSM-S-211_to_OSM-S-220

Original Sources

Attempts:

http://malaria.ourexperiment.org/uri/54c 

GitHub Link

 

Biological Data

N/A

Synonyms

AEW 128

FC1=C(F)C=C([I+]C2=C([CH2+])C=C(C)C=C2C)C=C1

InChI=1S/C15H14F2I/c1-9-6-10(2)15(11(3)7-9)18-12-4-5-13(16)14(17)8-12/h4-8H,1-3H3/q+1

HTOMECXYWUWECF-UHFFFAOYSA-N

(3,4-difluorophenyl)(mesityl)iodonium triflate

Attached Files
8th May 2014 @ 05:28
Osm: OSM-S-211_to_OSM-S-220

OSM-S-220

Original Sources

Original synthesis of related compound found in MMV briefing document found in this post:A New Triazolopyrazine Series for OSM - Series 4

See OSM-S-219 for synthesis of related compound

Attempts:

Synthesis of 5-chloro-3-(4-chlorophenyl)-[1,2,4]triazolo[4,3-a]pyrazine (JU 8-1)

GitHub Link

 

Biological Data

Single Shot Potencies for Compounds Submitted to GSK

Synonyms

JU 8

ClC1=CN=CC2=NN=C(C3=CC=C(Cl)C=C3)N21

InChI=1S/C11H6Cl2N4/c12-8-3-1-7(2-4-8)11-16-15-10-6-14-5-9(13)17(10)11/h1-6H

VCWFDFYRPOTNNX-UHFFFAOYSA-N

5-chloro-3-(4-chlorophenyl)-[1,2,4]triazolo[4,3-a]pyrazine

Linked Posts
Attached Files
8th May 2014 @ 04:00
Osm: OSM-S-211_to_OSM-S-220

Original Sources

Original synthesis found in MMV briefing document found in this post:A New Triazolopyrazine Series for OSM - Series 4

Other attempts:

Synthesis of 4-(5-Chloro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)benzonitrile (JU 3-8)

Synthesis of 4-(5-Chloro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)benzonitrile (JU 3-7)

Synthesis of 4-(5-Chloro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)benzonitrile (JU 3-6)

Synthesis of 4-(5-Chloro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)benzonitrile (JU 3-5)

Synthesis of 4-(5-Chloro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)benzonitrile (JU 3-4)

Synthesis of 4-(5-Chloro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)benzonitrile (JU 3-3)

Synthesis of 4-(5-Chloro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)benzonitrile (JU 3-2)

Synthesis of 4-(5-Chloro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)benzonitrile (JU 3-1)

 

Synthesis of 4-(5-chloro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)benzonitrile (AEW 97-9)

4-(5-Chloro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)benzonitrile (AEW 97-8)

4-(5-Chloro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)benzonitrile (AEW 97-7)

4-(5-Chloro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)benzonitrile (AEW 97-6)

4-(5-Chloro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)benzonitrile (AEW 97-5)

4-(5-Chloro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)benzonitrile (AEW 97-4)

4-(5-Chloro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)benzonitrile (AEW 97-3)

4-(5-Chloro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)benzonitrile (AEW 97-2)


GitHub Link

 

Biological Data

Single Shot Potencies for Compounds Submitted to GSK

Synonyms

AEW 97

JU 3

ClC1=CN=CC2=NN=C(C3=CC=C(C#N)C=C3)N21

InChI=1S/C12H6ClN5/c13-10-6-15-7-11-16-17-12(18(10)11)9-3-1-8(5-14)2-4-9/h1-4,6-7H

IXZMOLDGRAEJRY-UHFFFAOYSA-N

4-(5-chloro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)benzonitrile

Linked Posts
Attached Files