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27th March 2013 @ 01:55
Osm: OSM-S-91_to_OSM-S-100


OSM-S-100

Original Sources

Hydrolysis of MD 17-1 to give 2-((1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carbonyl)oxy)propanoic acid (MD 18-1)

Hydrolysis of MD 17-1 to give 2-((1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carbonyl)oxy)propanoic acid (MD 18-3)

Synthesis of 2-((1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carbonyl)oxy)propanoic acid (AEW 73-1)

Failed: Synthesis of 2-((1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carbonyl)oxy)propanoic acid (MD 19-1)

Biological Data

3D7 - Avery - Biological Activities of OSM-S-96 through 105

Synonyms

AEW 73, MD 18

FC1=CC=C(N2C(C)=CC(C(OC(C)C(O)=O)=O)=C2C)C=C1

InChI=1S/C16H16FNO4/c1-9-8-14(16(21)22-11(3)15(19)20)10(2)18(9)13-6-4-12(17)5-7-13/h4-8,11H,1-3H3,(H,19,20)

CLQCMRDHQCCPEN-UHFFFAOYSA-N

2-((1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carbonyl)oxy)propanoic acid

Attached Files
27th March 2013 @ 01:54
Osm: OSM-S-91_to_OSM-S-100


OSM-S-98

Original Sources

 EDC Coupling of MNR51 with Dimethylamine to give MNR52-1

Biological Data

3D7 - Avery - Biological Activities of OSM-S-96 through 105

Synonyms

MNR 52

FC1=CC=C(N2C(C)=CC(C(CCC(N(C)C)=O)=O)=C2C)C=C1

InChI=1S/C18H21FN2O2/c1-12-11-16(17(22)9-10-18(23)20(3)4)13(2)21(12)15-7-5-14(19)6-8-15/h5-8,11H,9-10H2,1-4H3

JSMYECUHSRLQOF-UHFFFAOYSA-N

4-(1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-N,N-dimethyl-4-oxobutanamide

Attached Files
27th March 2013 @ 01:52
Osm: OSM-S-91_to_OSM-S-100

OSM-S-97

Original Sources

Friedels-Craft Acylation of AEW1-1 to give MNR51-1

Friedels-Craft Acylation of AEW1-1 to give MNR51-2

Biological Data

3D7 - Avery - Biological Activities of OSM-S-96 through 105

Synonyms

MNR 51

FC1=CC=C(N2C(C)=CC(C(CCC(O)=O)=O)=C2C)C=C1

InChI=1S/C16H16FNO3/c1-10-9-14(15(19)7-8-16(20)21)11(2)18(10)13-5-3-12(17)4-6-13/h3-6,9H,7-8H2,1-2H3,(H,20,21)

GNRWSIUEZUQINP-UHFFFAOYSA-N

4-(1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-4-oxobutanoic acid

Attached Files
27th March 2013 @ 01:50
Osm: OSM-S-91_to_OSM-S-100

OSM-S-96

Original Sources

Cyclodehydration of coupled pyrazole core MJT5-1 and subsequent oxidation to oxazole (MJT 6-1)

Biological Data

3D7 - Avery - Biological Activities of OSM-S-96 through 105

Synonyms

MJT 6

FC1=CC=C(N2N=CC(C3=NC(C(OC)=O)=CO3)=C2C)C=C1

InChI=1S/C15H12FN3O3/c1-9-12(14-18-13(8-22-14)15(20)21-2)7-17-19(9)11-5-3-10(16)4-6-11/h3-8H,1-2H3

MXBGFPWDTSYZMH-UHFFFAOYSA-N

methyl 2-(1-(4-fluorophenyl)-5-methyl-1H-pyrazol-4-yl)oxazole-4-carboxylate

Attached Files