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26th March 2013 @ 07:09
Osm: OSM-S-41_to_OSM-S-50


OSM-S-50

Original Sources

Acetylation of para-methyl arylpyrrole near neighbour analogue (ZYH 17-1)

Resynthesis of (Z)-N-(5-((2,5-dimethyl-1-(p-tolyl)-1H-pyrrol-3-yl)methylene)-4-oxo-4,5-dihydrothiazol-2-yl)-N-phenylacetamide (AEW 79-1, OSM-S-50)

Biological Data

3D7, K1 and HEK293 - Avery - Second Round of Evaluation by the Avery Lab

3D7 - Ralph - Second Round Biological evaluation by James Pham and Stuart Ralph

3D7 - GSK - Second Round of Evaluation by GSK Tres Cantos

GSK DHODH Assay

Synonyms

ZYH 17, AEW 79

O=C(N=C(S/1)N(C2=CC=CC=C2)C(C)=O)C1=C\C3=C(C)N(C4=CC=C(C)C=C4)C(C)=C3

InChI=1S/C25H23N3O2S/c1-16-10-12-22(13-11-16)27-17(2)14-20(18(27)3)15-23-24(30)26-25(31-23)28(19(4)29)21-8-6-5-7-9-21/h5-15H,1-4H3/b23-15-

RZFIAJJLMRMIBB-HAHDFKILSA-N

(Z)-N-(5-((2,5-dimethyl-1-(p-tolyl)-1H-pyrrol-3-yl)methylene)-4-oxo-4,5-dihydrothiazol-2-yl)-N-phenylacetamide

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26th March 2013 @ 07:07
Osm: OSM-S-41_to_OSM-S-50


OSM-S-49

Original Sources

Acetylation of unsubstituted arylpyrrole near neighbour analogue (ZYH 16-1)

Biological Data

3D7, K1 and HEK293 - Avery - Second Round of Evaluation by the Avery Lab

3D7 - Ralph - Second Round Biological evaluation by James Pham and Stuart Ralph

3D7 - GSK - Second Round of Evaluation by GSK Tres Cantos

GSK DHODH Assay

Synonyms

ZYH 16

O=C(N=C(S/1)N(C2=CC=CC=C2)C(C)=O)C1=C\C3=C(C)N(C4=CC=CC=C4)C(C)=C3

InChI=1S/C24H21N3O2S/c1-16-14-19(17(2)26(16)20-10-6-4-7-11-20)15-22-23(29)25-24(30-22)27(18(3)28)21-12-8-5-9-13-21/h4-15H,1-3H3/b22-15-

HYCHBJJSXVXDSY-JCMHNJIXSA-N

(Z)-N-(5-((2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)methylene)-4-oxo-4,5-dihydrothiazol-2-yl)-N-phenylacetamide

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26th March 2013 @ 07:06
Osm: OSM-S-41_to_OSM-S-50

OSM-S-48

Original Sources

Synthesis of benzocaine arylpyrrole based near neighbour analogue (ZYH 15-1)

Biological Data

3D7, K1 and HEK293 - Avery - Second Round of Evaluation by the Avery Lab

3D7 - Ralph - Second Round Biological evaluation by James Pham and Stuart Ralph

3D7 - GSK - Second Round of Evaluation by GSK Tres Cantos

GSK DHODH Assay

Synonyms

ZYH 15

CCOC(C1=CC=C(N2C(C)=CC(/C=C(C(N/3)=O)\SC3=N/C4=CC=CC=C4)=C2C)C=C1)=O

InChI=1S/C25H23N3O3S/c1-4-31-24(30)18-10-12-21(13-11-18)28-16(2)14-19(17(28)3)15-22-23(29)27-25(32-22)26-20-8-6-5-7-9-20/h5-15H,4H2,1-3H3,(H,26,27,29)/b22-15-

RDXBLRRUYBTFEI-JCMHNJIXSA-N

ethyl 4-(2,5-dimethyl-3-((Z)-((Z)-4-oxo-2-(phenylimino)thiazolidin-5-ylidene)methyl)-1H-pyrrol-1-yl)benzoate

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26th March 2013 @ 07:05
Osm: OSM-S-41_to_OSM-S-50


OSM-S-47

Original Sources

Synthesis of diphenyl thiazolidinone (ZYH 14-1)

Synthesis of N,N-diphenylthiourea and 3-phenyl-2-(phenylimino)thiazolidin-4-one (SBBH-1-7)

Synonyms

ZYH 14, SBBH-1-7

O=C1CS/C(N1C2=CC=CC=C2)=N\C3=CC=CC=C3

InChI=1S/C15H12N2OS/c18-14-11-19-15(16-12-7-3-1-4-8-12)17(14)13-9-5-2-6-10-13/h1-10H,11H2/b16-15-

RAVFWIXHMXTJQU-NXVVXOECSA-N

(Z)-3-phenyl-2-(phenylimino)thiazolidin-4-one

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26th March 2013 @ 07:04
Osm: OSM-S-41_to_OSM-S-50


OSM-S-46

Original Sources

Synthesis of aldehyde from benzocaine-based arylpyrrole (ZYH 13-1)

Synonyms

ZYH 13

CC1=C(C=O)C=C(C)N1C2=CC=C(C(OCC)=O)C=C2

InChI=1S/C16H17NO3/c1-4-20-16(19)13-5-7-15(8-6-13)17-11(2)9-14(10-18)12(17)3/h5-10H,4H2,1-3H3

INHIPLWUOJQIIQ-UHFFFAOYSA-N

ethyl 4-(3-formyl-2,5-dimethyl-1H-pyrrol-1-yl)benzoate

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