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26th March 2013 @ 06:35
Osm: OSM-S-31_to_OSM-S-40


OSM-S-40

Original Sources

Synthesis of ethyl ester substituted arylpyrrole (ZYH 8-1)

Synonyms

ZYH 8

CC1=CC=C(C)N1C2=CC=C(C(OCC)=O)C=C2

InChI=1S/C15H17NO2/c1-4-18-15(17)13-7-9-14(10-8-13)16-11(2)5-6-12(16)3/h5-10H,4H2,1-3H3

FIQJDBIRRVQTJN-UHFFFAOYSA-N

ethyl 4-(2,5-dimethyl-1H-pyrrol-1-yl)benzoate

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26th March 2013 @ 06:34
Osm: OSM-S-31_to_OSM-S-40


OSM-S-39

Original Sources

Synthesis of 3,5-bis(trifluoromethyl) arylpyrrole based near neighbour analogue (ZYH 7-1)

Synthesis of 3,5-bis(trifluoromethyl) arylpyrrole based near neighbour analogue (ZYH 7-2)

Biological Data

3D7, K1 and HEK293 - Avery - Second Round of Evaluation by the Avery Lab

3D7 - Ralph - Second Round Biological evaluation by James Pham and Stuart Ralph

3D7 - GSK - Second Round of Evaluation by GSK Tres Cantos

Metabolism - Metabolism and Solubility Results

Late stage gametocyte testing of a sample set of GSK-Arylpyrrole Series

GSK DHODH Assay

Synonyms

ZYH 7

CC1=CC(/C=C(C(N/2)=O)\SC2=N/C3=CC=CC=C3)=C(C)N1C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4

InChI=1S/C24H17F6N3OS/c1-13-8-15(9-20-21(34)32-22(35-20)31-18-6-4-3-5-7-18)14(2)33(13)19-11-16(23(25,26)27)10-17(12-19)24(28,29)30/h3-12H,1-2H3,(H,31,32,34)/b20-9-

GVGNOLWIUGQIHW-UKWGHVSLSA-N

(2Z,5Z)-5-((1-(3,5-bis(trifluoromethyl)phenyl)-2,5-dimethyl-1H-pyrrol-3-yl)methylene)-2-(phenylimino)thiazolidin-4-one

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26th March 2013 @ 06:33
Osm: OSM-S-31_to_OSM-S-40

OSM-S-38

Original Sources

Synthesis of p-trifluoromethyl arylpyrrole based near-neighbour analogue (ZYH 6-1)

Scale up of preparation of 4-trifluoromethyl arylpyrrole based near neighbour (ZYH 6-2)

Biological Data

3D7, K1 and HEK293 - Avery - Second Round of Evaluation by the Avery Lab

3D7 - Ralph - Second Round Biological evaluation by James Pham and Stuart Ralph

3D7 - GSK - Second Round of Evaluation by GSK Tres Cantos

Metabolism - Metabolism and Solubility Results

Late stage gametocyte testing of a sample set of GSK-Arylpyrrole Series

GSK DHODH Assay

Synonyms

ZYH 6

CC1=CC(/C=C(C(N/2)=O)\SC2=N/C3=CC=CC=C3)=C(C)N1C(C=C4)=CC=C4C(F)(F)F

InChI=1S/C23H18F3N3OS/c1-14-12-16(15(2)29(14)19-10-8-17(9-11-19)23(24,25)26)13-20-21(30)28-22(31-20)27-18-6-4-3-5-7-18/h3-13H,1-2H3,(H,27,28,30)/b20-13-

YBBWTVGRVHTTDD-MOSHPQCFSA-N

(2Z,5Z)-5-((2,5-dimethyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrrol-3-yl)methylene)-2-(phenylimino)thiazolidin-4-one

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26th March 2013 @ 06:31
Osm: OSM-S-31_to_OSM-S-40

OSM-S-37

Original Sources

Synthesis of p-methyl arylpyrrole based near neighbour (ZYH 5-1)

Synthesis of (2Z,5Z)-5-((2,5-dimethyl-1-(p-tolyl)-1H-pyrrol-3-yl)methylene)-2-(phenylimino)thiazolidin-4-one (AEW 76-1, OSM-S-37)

Synthesis of (2Z,5Z)-5-((2,5-dimethyl-1-(p-tolyl)-1H-pyrrol-3-yl)methylene)-2-(phenylimino)thiazolidin-4-one

Biological Data

3D7, K1 and HEK293 - Avery - Second Round of Evaluation by the Avery Lab

3D7 - Ralph - Second Round Biological evaluation by James Pham and Stuart Ralph

3D7 - GSK - Second Round of Evaluation by GSK Tres Cantos

Metabolism - Metabolism and Solubility Results

GSK DHODH Assay

Synonyms

ZHY 5, AEW 76

CC1=CC=C(N2C(C)=C(/C=C(C(N/3)=O)\SC3=N/C4=CC=CC=C4)C=C2C)C=C1

InChI=1S/C23H21N3OS/c1-15-9-11-20(12-10-15)26-16(2)13-18(17(26)3)14-21-22(27)25-23(28-21)24-19-7-5-4-6-8-19/h4-14H,1-3H3,(H,24,25,27)/b21-14-

XCTPMKNSBDOHRB-STZFKDTASA-N

(2Z,5Z)-5-((2,5-dimethyl-1-(p-tolyl)-1H-pyrrol-3-yl)methylene)-2-(phenylimino)thiazolidin-4-one

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26th March 2013 @ 06:30
Osm: OSM-S-31_to_OSM-S-40

OSM-S-36

Original Sources

Preparation of 2,5-dimethyl-1-(3,5-bis(trifluoromethyl)phenyl)-1H-pyrrole-3-carbaldehyde (ZYH 4-1)

Preparation of 2,5-dimethyl-1-(3,5-bis(trifluoromethyl)phenyl)-1H-pyrrole-3-carbaldehyde (ZYH 4-2)

Preparation of bis(trifluoromethyl) arylpyrrole aldehyde (ZYH 4-3)

Synonyms

ZHY 4

CC1=C(C=O)C=C(C)N1C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2

InChI=1S/C15H11F6NO/c1-8-3-10(7-23)9(2)22(8)13-5-11(14(16,17)18)4-12(6-13)15(19,20)21/h3-7H,1-2H3

ZPNXIXBDNHGLNY-UHFFFAOYSA-N

1-(3,5-bis(trifluoromethyl)phenyl)-2,5-dimethyl-1H-pyrrole-3-carbaldehyde

Attached Files