All Notebooks | Help | Support | About
6th May 2014 @ 03:57
Osm: OSM-S-201_to_OSM-S-210

Original Sources

 

Biological Data

Single Shot Potencies for Compounds Submitted to GSK

Related links:

 

Synonyms

KAB110

C1(CCOC23CCN(CC4=CC(OCCO5)=C5C=C4)CC3)=C2C=CS1

InChI=1S/C20H23NO3S/c1-2-17-18(23-11-10-22-17)13-15(1)14-21-7-5-20(6-8-21)16-4-12-25-19(16)3-9-24-20/h1-2,4,12-13H,3,5-11,14H2

NCRPMBWORFWNGT-UHFFFAOYSA-N

1-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methyl)-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran]

Linked Posts
Attached Files
6th May 2014 @ 03:39
Osm: OSM-S-201_to_OSM-S-210

Original Sources

 

Biological Data

Single Shot Potencies for Compounds Submitted to GSK

Related links:

 

Synonyms

KAB90

C1(CCOC23CCN(CC4=CC=CC=C4)CC3)=C2C=CS1

InChI=1S/C18H21NOS/c1-2-4-15(5-3-1)14-19-10-8-18(9-11-19)16-7-13-21-17(16)6-12-20-18/h1-5,7,13H,6,8-12,14H2

WRPOPKKINJVHKF-UHFFFAOYSA-N

1-benzyl-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran]

Linked Posts
Attached Files
6th May 2014 @ 02:34
Osm: OSM-S-201_to_OSM-S-210

Original Sources

Compound originally sourced from MMV as an enantiomerically enriched compound (MMV669884). OSM inherited data at start of Series 4 project.

Synthesis of 4-(5-(2-(3,4-difluorophenyl)-2-methoxyethoxy)-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)benzonitrile (AEW 145-1)

GitHub Tag: #166

Biological Data

xxx measured

Related data for enantiomerically enriched compound (OSM-S-218, MMV669884).

OSM inherited data at start of Series 4 project.

??? - data inherited.

Metabolism ID Study for Three Triazolopyrazines

Assay Methods for Inherited Series 4 Compounds

Evaluation against Pb. Liver Schizonts

hERG Data

Single Shot Potencies for Compounds Submitted to GSK

Related links:

Data for enantiomerically enriched compound (OSM-S-218, MMV669884).

Similarity of Series 4 Compounds to KAI407

Synonyms

AEW 145

FC1=C(F)C=CC(C(OC)COC2=CN=CC3=NN=C(C4=CC=C(C#N)C=C4)N32)=C1

InChI=1S/C21H15F2N5O2/c1-29-18(15-6-7-16(22)17(23)8-15)12-30-20-11-25-10-19-26-27-21(28(19)20)14-4-2-13(9-24)3-5-14/h2-8,10-11,18H,12H2,1H3

PERKBMZWWUEZNJ-UHFFFAOYSA-N

4-(5-(2-(3,4-difluorophenyl)-2-methoxyethoxy)-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)benzonitrile

Linked Posts
Attached Files
6th May 2014 @ 01:29
Osm: OSM-S-201_to_OSM-S-210

Original Sources

Synthesis of N-(3,5-bis(trifluoromethyl)phenyl)-3-(4-(difluoromethoxy)phenyl)-[1,2,4]triazolo[4,3-a]pyrazine-5-carboxamide (AEW 120-1)

GitHub Tag 155

Biological Data

Single Shot Potencies for Compounds Submitted to GSK

Synonyms

AEW 120

FC(F)OC(C=C1)=CC=C1C2=NN=C3C=NC=C(C(NC4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)=O)N32

InChI=1S/C21H11F8N5O2/c22-19(23)36-14-3-1-10(2-4-14)17-33-32-16-9-30-8-15(34(16)17)18(35)31-13-6-11(20(24,25)26)5-12(7-13)21(27,28)29/h1-9,19H,(H,31,35)

GCJUFPUQPKTUOT-UHFFFAOYSA-N

N-(3,5-bis(trifluoromethyl)phenyl)-3-(4-(difluoromethoxy)phenyl)-[1,2,4]triazolo[4,3-a]pyrazine-5-carboxamide

Linked Posts
Attached Files
5th May 2014 @ 09:32
Osm: OSM-S-201_to_OSM-S-210

OSM-S-205

Original Sources

Synthesis of N-(3-chloro-2-fluorophenyl)-3-(4-cyanophenyl)-[1,2,4]triazolo[4,3-a]pyrazine-5-carboxamide (TM 18-1)

Biological Data

N/A

Synonyms

TM 18

O=C(NC1=C(F)C(Cl)=CC=C1)C2=CN=CC(N23)=NN=C3C4=CC=C(C#N)C=C4

InChI=1S/C19H10ClFN6O/c20-13-2-1-3-14(17(13)21)24-19(28)15-9-23-10-16-25-26-18(27(15)16)12-6-4-11(8-22)5-7-12/h1-7,9-10H,(H,24,28)

IDMCTWULSGGMQZ-UHFFFAOYSA-N

N-(3-chloro-2-fluorophenyl)-3-(4-cyanophenyl)-[1,2,4]triazolo[4,3-a]pyrazine-5-carboxamide

Attached Files