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1st May 2014 @ 06:43
Osm: OSM-S-181_to_OSM-S-190

OSM-S-190

Original Sources

Synthesis of 4-(5-((3-chlorophenethyl)amino)-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)benzonitrile (JU 11-1)

GitHub Link

Issue #186

Biological Data

Single Shot Potencies for Compounds Submitted to GSK

Synonyms

JU 11

N#CC(C=C1)=CC=C1C2=NN=C3C=NC=C(NCCC4=CC(Cl)=CC=C4)N32

InChI=1S/C20H15ClN6/c21-17-3-1-2-14(10-17)8-9-24-18-12-23-13-19-25-26-20(27(18)19)16-6-4-15(11-22)5-7-16/h1-7,10,12-13,24H,8-9H2

XDIXATSCLPARDX-UHFFFAOYSA-N

4-(5-((3-chlorophenethyl)amino)-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)benzonitrile

Linked Posts
Attached Files
1st May 2014 @ 06:39
Osm: OSM-S-181_to_OSM-S-190

OSM-S-189

Original Sources

Synthesis of 4-(5-(2-chlorophenethoxy)-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)benzonitrile (JU 10-1)

GitHub Link

Issue #183

Biological Data

Single Shot Potencies for Compounds Submitted to GSK

Synonyms

JU 10

N#CC(C=C1)=CC=C1C2=NN=C3C=NC=C(OCCC4=CC=CC=C4Cl)N32

InChI=1S/C20H14ClN5O/c21-17-4-2-1-3-15(17)9-10-27-19-13-23-12-18-24-25-20(26(18)19)16-7-5-14(11-22)6-8-16/h1-8,12-13H,9-10H2

DQNFHRXLTAOFIL-UHFFFAOYSA-N

4-(5-(2-chlorophenethoxy)-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)benzonitrile

Linked Posts
Attached Files
1st May 2014 @ 06:34
Osm: OSM-S-181_to_OSM-S-190

OSM-S-188

Original Sources

Synthesis of 4-(5-(phenethylthio)-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)benzonitrile (JU 9-1)

GitHub Link

Issue #182

Biological Data

Single Shot Potencies for Compounds Submitted to GSK

Synonyms

JU 9

N#CC(C=C1)=CC=C1C2=NN=C3C=NC=C(SCCC4=CC=CC=C4)N32

InChI=1S/C20H15N5S/c21-12-16-6-8-17(9-7-16)20-24-23-18-13-22-14-19(25(18)20)26-11-10-15-4-2-1-3-5-15/h1-9,13-14H,10-11H2

UNOPMJXTFSQGHI-UHFFFAOYSA-N

4-(5-(phenethylthio)-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)benzonitrile

Linked Posts
Attached Files
1st May 2014 @ 06:13
Osm: OSM-S-181_to_OSM-S-190

OSM-S-187

Original Sources

Synthesis of 4-(5-phenethoxy-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)benzonitrile (JU 6-2)

Synthesis of 4-(5-phenethoxy-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)benzonitrile (JU 6-1)

GitHub Link

Issue #165

Biological Data

Single Shot Potencies for Compounds Submitted to GSK

Synonyms

JU 6

N#CC(C=C1)=CC=C1C2=NN=C3C=NC=C(OCCC4=CC=CC=C4)N32

InChI=1S/C20H15N5O/c21-12-16-6-8-17(9-7-16)20-24-23-18-13-22-14-19(25(18)20)26-11-10-15-4-2-1-3-5-15/h1-9,13-14H,10-11H2

ZUPHNBXHMXOSSS-UHFFFAOYSA-N

4-(5-phenethoxy-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)benzonitrile


Linked Posts
Attached Files
9th April 2014 @ 07:21
Osm: OSM-S-181_to_OSM-S-190

Original Sources

Compound originally sourced from MMV. OSM inherited data at start of Series 4 project.

Biological Data

>10 000 - data inherited.

Assay Methods for Inherited Series 4 Compounds

Synonyms

MMV669023

O=C(N1CCN(S(=O)(C)=O)CC1)C2=CN=CC3=NN=C(C4=CC=C(OC(F)F)C=C4)N32

InChI=1S/C18H18F2N6O4S/c1-31(28,29)25-8-6-24(7-9-25)17(27)14-10-21-11-15-22-23-16(26(14)15)12-2-4-13(5-3-12)30-18(19)20/h2-5,10-11,18H,6-9H2,1H3

InChI=1S/C18H18F2N6O4S/c1-31(28,29)25-8-6-24(7-9-25)17(27)14-10-21-11-15-22-23-16(26(14)15)12-2-4-13(5-3-12)30-18(19)20/h2-5,10-11,18H,6-9H2,1H3

(3-(4-(difluoromethoxy)phenyl)-[1,2,4]triazolo[4,3-a]pyrazin-5-yl)(4-(methylsulfonyl)piperazin-1-yl)methanone

Attached Files