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31st August 2014 @ 19:29
Osm: OSM-S-131_to_OSM-S-140

 OSM-S-140

Context

OSM Series 3

Original Sources

need

Biological Evaluation

need

Synonyms

need

 

Attached Files
9th February 2014 @ 07:59
Osm: OSM-S-131_to_OSM-S-140

OSM-S-139

Original Sources

Synthesis of 6-bromothieno[3,2-d]pyrimidin-4-amine (21-1) (unsuccessful)

Synthesis of 6-bromothieno[3,2-d]pyrimidin-4-amine (JRC 40-1)

Synthesis of 6-bromothieno[3,2-d]pyrimidin-4-amine (JRC 40-2)

Amination of bromochlorothienopyrimidine (AT-6-1)

Amination of bromochlorothienopyrimidine (AT-6-2)

Amination of bromochlorothienopyrimidine (AT-6-3)

Amination of bromochlorothienopyrimidine (AT-6-4)

Amination of chlorobromothienopyrimidine (AT-6-5)

Synthesis of 6-Bromothieno[3,2-d]pyrimidin-4-amine (AEW 100-1) (unsuccessful)

Synthesis of 6-Bromothieno[3,2-d]pyrimidin-4-amine (AEW 100-2) (unsuccessful)

Synthesis of 6-Bromothieno[3,2-d]pyrimidin-4-amine (AEW 100-3)

Synthesis of 6-Bromothieno[3,2-d]pyrimidin-4-amine (AEW 100-4)

Synthesis of 6-Bromothieno[3,2-d]pyrimidin-4-amine (AEW 100-5)

Synthesis of 6-Bromothieno[3,2-d]pyrimidin-4-amine (CT 3-1)

Synthesis of 6-Bromothieno[3,2-d]pyrimidin-4-amine (CT 3-2)

Synthesis of 6-Bromothieno[3,2-d]pyrimidin-4-amine (CT 3-3)

Synthesis of 6-Bromothieno[3,2-d]pyrimidin-4-amine (CT 3-4)

Synthesis of 6-Bromothieno[3,2-d]pyrimidin-4-amine (CT 3-5)

Synthesis of 6-Bromothieno[3,2-d]pyrimidin-4-amine (CT 3-6)

Synthesis of 6-Bromothieno[3,2-d]pyrimidin-4-amine (CT 3-7)

Biological Evaluation

Single Shot Potencies for Compounds Submitted to GSK

Synonyms

AT 6, JRC 40, AEW 100, CT 3

 

BrC1=CC2=NC=NC(N)=C2S1

InChI=1S/C6H4BrN3S/c7-4-1-3-5(11-4)6(8)10-2-9-3/h1-2H,(H2,8,9,10)

VKZWSZNMIMJBJX-UHFFFAOYSA-N

6-bromothieno[3,2-d]pyrimidin-4-amine

Linked Posts
24th April 2013 @ 06:31
Osm: OSM-S-131_to_OSM-S-140

OSM-S-138

Original Sources

Reduction of MNR82 to give MNR121-1

Biological Data

Biological Activities of OSM-S-117 through 138

Synonyms

MNR 121

CC1=CC(/C=C(S/2)/C(NC2=N\C3=CC=CC=C3)=O)=C(C)N1C4=CC=C(N)C=C4

InChI=1S/C22H20N4OS/c1-14-12-16(15(2)26(14)19-10-8-17(23)9-11-19)13-20-21(27)25-22(28-20)24-18-6-4-3-5-7-18/h3-13H,23H2,1-2H3,(H,24,25,27)/b20-13-

HRLJSVOIZGABSH-MOSHPQCFSA-N

(2Z,5Z)-5-((1-(4-aminophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)methylene)-2-(phenylimino)thiazolidin-4-one

Attached Files
24th April 2013 @ 06:30
Osm: OSM-S-131_to_OSM-S-140

OSM-S-137

Original Sources

Microwave Assisted Arylation of MNR115 to give MNR120-1

Biological Data

Biological Activities of OSM-S-117 through 138

Synonyms

Fc1ccc(cc1)CN2CCN(CC2)c3ncnc4cc(sc34)c5cccc(c5)S(N)(=O)=O

InChI=1S/C23H22FN5O2S2/c24-18-6-4-16(5-7-18)14-28-8-10-29(11-9-28)23-22-20(26-15-27-23)13-21(32-22)17-2-1-3-19(12-17)33(25,30)31/h1-7,12-13,15H,8-11,14H2,(H2,25,30,31)

OWXZZWFFXSEZNL-UHFFFAOYSA-N

NAME NEEDED

24th April 2013 @ 06:29
Osm: OSM-S-131_to_OSM-S-140

OSM-S-136

Original Sources

Bromination of MNR113-1 to give MNR115-2

Bromination of Crude MNR113-1 to give MNR115-1

Bromination of Crude AEW 53-1 to give (AEW 70-1)

Biological Data

Biological Activities of OSM-S-117 through 138

Synonyms

Fc1ccc(cc1)CN2CCN(CC2)c3ncnc4cc(Br)sc34

InChI=1S/C17H16BrFN4S/c18-15-9-14-16(24-15)17(21-11-20-14)23-7-5-22(6-8-23)10-12-1-3-13(19)4-2-12/h1-4,9,11H,5-8,10H2

DQEWYYDIDSUSJB-UHFFFAOYSA-N

6-bromo-4-[4-(4-fluorobenzyl)piperazin-1-yl]thieno[3,2-d]pyrimidine