All Notebooks | Help | Support | About
26th March 2013 @ 06:13
Osm: OSM-S-11_to_OSM-S-20

OSM-S-20

Original Sources


Synthesis of pyrrole acid chloride of PMY 8-3 (PMY 32-1)

Synthesis of pyrrole acid chloride of PMY 8-4 (PMY 32-2)

Synthesis of pyrrole acid chloride (PMY 32-3)

Acid chloride mediated coupling of pyrrole acid with hydrazine hydrate (AEW 17-1)

Synonyms

PMY 32

FC1=CC=C(N2C(C)=CC(C(Cl)=O)=C2C)C=C1

InChI=1S/C13H11ClFNO/c1-8-7-12(13(14)17)9(2)16(8)11-5-3-10(15)4-6-11/h3-7H,1-2H3

PFYKYZUJWZEKFH-UHFFFAOYSA-N

1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carbonyl chloride

Attached Files
26th March 2013 @ 06:08
Osm: OSM-S-11_to_OSM-S-20

OSM-S-19

Original Sources

Failed: Coupling of pyrrole carboxylic acid PMY 8-3 and glycinamide (PMY 31-1)

Failed: Coupling of pyrrole carboxylic acid PMY 8-3 and glycinamide (PMY 31-2)

Failed: Coupling of pyrrole carboxylic acid PMY 8-3 and glycinamide (PMY 31-3)

Failed: Coupling of pyrrole carboxylic acid PMY 8-3 and glycinamide (PMY 31-4)

Coupling of pyrrole acid chloride PMY 32-2 and glycinamide (PMY 31-5)

Failed: Resynthesis of N-(2-amino-2-oxoethyl)-1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carboxamide, OSM-S-19 (AEW 59-1)

Resynthesis of N-(2-amino-2-oxoethyl)-1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carboxamide, OSM-S-19 (AEW 59-2)

Biological Data

3D7, K1 and HEK293 - Avery - Second Round of Evaluation by the Avery Lab

3D7 - Ralph - Second Round Biological evaluation by James Pham and Stuart Ralph

3D7 - GSK - Second Round of Evaluation by GSK Tres Cantos

GSK DHODH Assay

Synonyms

PMY 31, AEW 59

CC(N1C2=CC=C(F)C=C2)=CC(C(NCC(N)=O)=O)=C1C

InChI=1S/C15H16FN3O2/c1-9-7-13(15(21)18-8-14(17)20)10(2)19(9)12-5-3-11(16)4-6-12/h3-7H,8H2,1-2H3,(H2,17,20)(H,18,21)

NNGDJLZNBQLHHL-UHFFFAOYSA-N

N-(2-amino-2-oxoethyl)-1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carboxamide

Linked Posts
This post is linked by:
Attached Files
26th March 2013 @ 06:07
Osm: OSM-S-11_to_OSM-S-20

OSM-S-18

Original Sources

Failed: Hydrolysis of benzoyl protected glycinamide PMY 27-1 (PMY 28-1)

Failed: Hydrolysis of benzoyl protected glycinamide PMY 27-1 (PMY 28-2)

Deprotection of Boc-Gly-4-aminoantipyrine (PMY 30-1)

Deprotection of Boc-Gly-4-aminoantipyrine (PMY 30-2)

Deprotection of Boc-Gly-4-aminoantipyrine (PMY 30-3)

Synthesis of 2-amino-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)acetamide (AEW 64-1)

Synthesis of 2-amino-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)acetamide (AEW 64-2)

Synonyms

PMY 28, PMY 30, AEW 64

NCC(NC1=C(C)N(C)N(C2=CC=CC=C2)C1=O)=O

InChI=1S/C13H16N4O2/c1-9-12(15-11(18)8-14)13(19)17(16(9)2)10-6-4-3-5-7-10/h3-7H,8,14H2,1-2H3,(H,15,18)

CAOVTXITBPMFQE-UHFFFAOYSA-N

2-amino-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)acetamide

Attached Files
26th March 2013 @ 05:45
Osm: OSM-S-11_to_OSM-S-20

OSM-S-17


Original Sources

Coupling of Boc-Gly-OH and 4-aminoantipyrine (PMY 29-1)

Coupling of Boc-Gly-OH and 4-aminoantipyrine (PMY 29-2)

Resynthesis of tert-butyl (2-((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)amino)-2-oxoethyl)carbamate, OSM-S-17 (AEW 63-1)

Synthesis of tert-butyl (2-((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)amino)-2-oxoethyl)carbamate (AEW 72-1)

Resynthesis of tert-butyl (2-((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)amino)-2-oxoethyl)carbamate, OSM-S-17 (AEW 64-3)

Synonyms

PMY 29, AEW 63, AEW 72, AEW 64 (likely AEW 72 and 64 ought to be 63)

O=C(NC1=C(C)N(C)N(C2=CC=CC=C2)C1=O)CNC(OC(C)(C)C)=O

InChI=1S/C18H24N4O4/c1-12-15(20-14(23)11-19-17(25)26-18(2,3)4)16(24)22(21(12)5)13-9-7-6-8-10-13/h6-10H,11H2,1-5H3,(H,19,25)(H,20,23)

MUHIYEGCMCBELD-UHFFFAOYSA-N

tert-butyl (2-((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)amino)-2-oxoethyl)carbamate

Attached Files
26th March 2013 @ 05:44
Osm: OSM-S-11_to_OSM-S-20


OSM-S-16

Original Sources

Coupling of hippuric acid and 4-aminoantipyrine using T3P (PMY 27-1)

Coupling of hippuric acid and 4-aminoantipyrine using T3P (PMY 27-2)

Biological Data

3D7, K1 and HEK293 - Avery - Second Round of Evaluation by the Avery Lab

3D7 - GSK - Second Round of Evaluation by GSK Tres Cantos

GSK DHODH Assay

Synonyms

PMY 27

O=C(NC1=C(C)N(C)N(C2=CC=CC=C2)C1=O)CNC(C3=CC=CC=C3)=O

InChI=1S/C20H20N4O3/c1-14-18(20(27)24(23(14)2)16-11-7-4-8-12-16)22-17(25)13-21-19(26)15-9-5-3-6-10-15/h3-12H,13H2,1-2H3,(H,21,26)(H,22,25)

URWSDMBJVGVIQC-UHFFFAOYSA-N

N-(2-((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)amino)-2-oxoethyl)benzamide

Linked Posts
This post is linked by:
Attached Files