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27th March 2013 @ 02:08
Osm: OSM-S-101_to_OSM-S-110

OSM-S-110

Original Sources

Synthesis of Near Neighbour Analog MNR83-1

Biological Data

3D7 - Avery - Biological Activities of OSM-S-106 through 116

Synonyms

MNR 83

O=C(/C(S/1)=C/C2=C(C)N(C3=CC=C([N+]([O-])=O)C=C3)C(C)=C2)NC1=N\C4=CC(O)=CC=C4

InChI=1S/C22H18N4O4S/c1-13-10-15(14(2)25(13)17-6-8-18(9-7-17)26(29)30)11-20-21(28)24-22(31-20)23-16-4-3-5-19(27)12-16/h3-12,27H,1-2H3,(H,23,24,28)/b20-11-

NAHYEQMJTBIJRP-JAIQZWGSSA-N

(2Z,5Z)-5-((2,5-dimethyl-1-(4-nitrophenyl)-1H-pyrrol-3-yl)methylene)-2-((3-hydroxyphenyl)imino)thiazolidin-4-one

Attached Files
27th March 2013 @ 02:07
Osm: OSM-S-101_to_OSM-S-110

OSM-S-109

Original Sources

Synthesis of Near Neighbour Analog MNR82-1

Synthesis of Near Neighbour Analog MNR82-2

Biological Data

3D7 - Avery - Biological Activities of OSM-S-106 through 116

Synonyms

MNR 82

O=C(/C(S/1)=C/C2=C(C)N(C3=CC=C([N+]([O-])=O)C=C3)C(C)=C2)NC1=N\C4=CC=CC=C4

InChI=1S/C22H18N4O3S/c1-14-12-16(15(2)25(14)18-8-10-19(11-9-18)26(28)29)13-20-21(27)24-22(30-20)23-17-6-4-3-5-7-17/h3-13H,1-2H3,(H,23,24,27)/b20-13-

CHHZBZWZMLCOEW-MOSHPQCFSA-N

(2Z,5Z)-5-((2,5-dimethyl-1-(4-nitrophenyl)-1H-pyrrol-3-yl)methylene)-2-(phenylimino)thiazolidin-4-one

Attached Files
27th March 2013 @ 02:06
Osm: OSM-S-101_to_OSM-S-110

OSM-S-108

Original Sources

Synthesis of (2Z,5Z)-5-((2,5-dimethyl-1H-pyrrol-3-yl)methylene)-2-(phenylimino)thiazolidin-4-one (AEW 34-1)

Biological Data

3D7 - Avery - Biological Activities of OSM-S-106 through 116

Synonyms

AEW 34

O=C(/C(S/1)=C/C2=C(C)NC(C)=C2)NC1=N\C3=CC=CC=C3

InChI=1S/C16H15N3OS/c1-10-8-12(11(2)17-10)9-14-15(20)19-16(21-14)18-13-6-4-3-5-7-13/h3-9,17H,1-2H3,(H,18,19,20)/b14-9-

RARJKBCELXYZBB-ZROIWOOFSA-N

(2Z,5Z)-5-((2,5-dimethyl-1H-pyrrol-3-yl)methylene)-2-(phenylimino)thiazolidin-4-one

Attached Files
27th March 2013 @ 02:05
Osm: OSM-S-101_to_OSM-S-110

OSM-S-107

Original Sources

Nucleophilic Displacement of 4-chlorothienopyrimidine with Piperazine MNR107-1 to give MNR113-1

Synthesis of 4-(4-(4-fluorobenzyl)piperazin-1-yl)thieno[3,2-d]pyrimidine (AEW 53-1)'

Synonyms

Fc1ccc(cc1)CN2CCN(CC2)c3ncnc4ccsc34

InChI=1S/C17H17FN4S/c18-14-3-1-13(2-4-14)11-21-6-8-22(9-7-21)17-16-15(5-10-23-16)19-12-20-17/h1-5,10,12H,6-9,11H2

HYCIFMXWGMZZSB-UHFFFAOYSA-N

4-[4-(4-fluorobenzyl)piperazin-1-yl]thieno[3,2-d]pyrimidine

27th March 2013 @ 02:02
Osm: OSM-S-101_to_OSM-S-110

OSM-S-106

Original Sources

 Suzuki coupling using the same conditions that are used to generate boronate esters (JRC 50-2)

Synthesis of 3-(4-aminothieno[3,2-d]pyrimidin-6-yl)benzenesulfonamide (AB5-1) and 4-(4-aminothieno[3,2-d]pyrimidin-6-yl)benzenesulfonamide (AB6-1)

Repeat of the Suzuki coupling used in JRC50-2 - (MNR86-1)

Repeat of the Suzuki coupling used in JRC50-2 (AB8-1)

Upscaled repeat of the Suzuki coupling used in JRC50-2 (AB8-2)

Synthesis of 3-(4-aminothieno[3,2-d]pyrimidin-6-yl)benzenesulfonamide JRC 42-1 - early failed attempt

Github Issue 59

Biological Data

3D7 - Avery - Biological Activities of OSM-S-106 through 116

Late Stage Gametocyte Assay

Compounds sent for parasiste ion regulation assays at ANU

Compound List from Early Series to be sent to Kiaran Kirk

Liver stage malaria activities of OSM-S-106 and OSM-S-111 in Plasmodium berghei.

Metabolic and Kinetic Solubility Data for OSM-S-106 and OSM-S-111

Single Shot Potencies for Compounds Submitted to GSK

Ion Regulation Assay for OSM Series 1 and 3

Synonyms

NS(=O)(=O)c1cccc(c1)c2cc3ncnc(N)c3s2

InChI=1S/C12H10N4O2S2/c13-12-11-9(15-6-16-12)5-10(19-11)7-2-1-3-8(4-7)20(14,17)18/h1-6H,(H2,13,15,16)(H2,14,17,18)

MQMXDJVOZKMSNT-UHFFFAOYSA-N

3-(4-aminothieno[3,2-d]pyrimidin-6-yl)benzenesulfonamide

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