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3rd April 2012 @ 01:19
Synthesis of 4-H near neighbour ZYH 3-1

PMY47-1.png

Reaction Start Time: 10.00 03/04/12
PMY 13-1 (148 mg, 0.77 mmol, 1.0 equiv.) and piperidine (115 μL, 1.16 mmol, 1.5 equiv.) were dissolved in EtOH (10 mL). LMW 4-1 (168 mg, 0.77 mmol, 1.0 equiv.) was added as a solution in EtOH (3 mL) and the reaction heated to 60 °C. The reaction turns to a yellow suspension after approx 45 mins. After 4.5 hours, the reaction was cooled to room temperature then filtered and dried overnight (235 mg, 81% of theory).

See also:
Synthesis of phenyliminothiazolidinone-substituted arylpyrrole (ZYH 3-1)
Vilsmeier Haack Synthesis of 2,5-dimethyl-1-phenyl-1H-pyrrole-3-carbaldehyde (LMW 4-1)
Preparation of 2-phenyliminothiazolidin-4-one (PMY 13-1)

Risk and Hazard Assessment:
See: Synthesis of phenyliminothiazolidinone-substituted arylpyrrole (ZYH 3-1)
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