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11th April 2013 @ 06:41
 Starting material from [blog=7035]Synthesis of Near Neighbour Analog MNR82-2[/blog]  also [blog=6467]Synthesis of Near Neighbour Analog MNR82-1[/blog] Procedure as for Example 6 step b Hazard Assessment [data]4833[/data] Procedure To MNR82-2 (0.040 g, 0.1 mmol) in MeOH (2.4 mL) and DMF (0.6 mL) was added a catalytic amount of Palladium on charcoal (10%) and the reaction was stirred under an atmosphere of hydrogen overnight.  The reaction was then filtered through celite and concentrated.  Crude NMR showed DMF was still present but the crude mixture was soluble in CDCl3.   Crude NMR [data]6177[/data][data]6179[/data] Colum 5% MeOH/CHCl3 [data]6175[/data]   Frac 9 -  as a yellow oil, upon adding DCM a solid formed.  DCM removed and dried.   Frac 10-17 - NMR   Conclusion   Strings Starting Materials InChI=1S/C22H18N4O3S/c1-14-12-16(15(2)25(14)18-8-10-19(11-9-18)26(28)29)13-20-21(27)24-22(30-20)23-17-6-4-3-5-7-17/h3-13H,1-2H3,(H,23,24,27)/b20-13- Product InChI=1S/C22H20N4OS/c1-14-12-16(15(2)26(14)19-10-8-17(23)9-11-19)13-20-21(27)25-22(28-20)24-18-6-4-3-5-7-18/h3-13H,23H2,1-2H3,(H,24,25,27)/b20-13-
Attached Files
MNR121_scheme.png
2013-04-12 15.42.04.jpg
mnr121-1_filter_CDCl3_1H.pdf
mnr121-1_filter_CDCl3.zip
Comments
Re: Reduction of MNR82 to give MNR121-1 by OSDD Malaria
26th January 2014 @ 23:05
OSM-S-138