All Notebooks | Help | Support | About
31st January 2013 @ 07:31
Mnr: MNR91-100

Synthesis of near neighbour analog MNR95-1 from pyrrole AEW49-1 and thiazolidinone MNR88-1.

 InChI=1S/C22H19N3O2S/c1-14-12-16(15(2)25(14)18-6-4-3-5-7-18)13-20-21(27)24-22(28-20)23-17-8-10-19(26)11-9-17/h3-13,26H,1-2H3,(H,23,24,27)/b20-13-

 

Hazard Assessment

HIRAC MNR82.pdf

Procedure

Thiazolidinone MNR88-1 (0.08 g, 0.4 mmol) was dissolved in ethanol (6 mL) and piperdine (0.06 mL, 0.6 mmol) was added.  AEW49-1 (0.080 g, 0.4 mmol) was added to the mixture, and the resulting solution was heated to 60 °C overnight.  The reaction was then allowed to cool to room temperature and the precipitate was filtered and washed with EtOH to give an orange solid (0.125 g, 0.32 mmol, 80%)

NMR

 

mnr95-1_1H.pdf
mnr95-1.zip

Conclusion

 Proton NMR looks good and sample is ready to send for testing, further characterisation still needed.

Strings

Starting Materials

InChI=1S/C13H13NO/c1-10-8-12(9-15)11(2)14(10)13-6-4-3-5-7-13/h3-9H,1-2H3

InChI=1S/C9H8N2O2S/c12-7-3-1-6(2-4-7)10-9-11-8(13)5-14-9/h1-4,12H,5H2,(H,10,11,13)

Product

InChI=1S/C22H19N3O2S/c1-14-12-16(15(2)25(14)18-6-4-3-5-7-18)13-20-21(27)24-22(28-20)23-17-8-10-19(26)11-9-17/h3-13,26H,1-2H3,(H,23,24,27)/b20-13-

Linked Posts
This post is linked by:
Attached Files
MNR95-1_table.PNG
mnr95-1_1H.pdf
MNR95_scheme.png
mnr95-1.zip
Comments
Re: Synthesis of Near Neighbour Analog MNR95-1 by OSDD Malaria
26th January 2014 @ 22:58
OSM-S-115