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31st January 2013 @ 07:27
Synthesis of near neighbour analog MNR94-1 from pyrrole AEW49-1 and thiazolidinone MNR70-2.     Hazard Assessment [data]4833[/data] Procedure Thiazolidinone  MNR70-2 (0.08 g, 0.4 mmol) was dissolved in ethanol (6 mL) and piperdine (0.06 mL, 0.6 mmol) was added.  AEW49-1 (0.080 g, 0.4 mmol) was added to the mixture, and the resulting solution was heated to 60 °C overnight. The reaction was then allowed to cool to room temperature and the precipitate was filtered and washed with EtOH to give a dark yellow solid (0.124 g, 0.32 mmol, 79%) NMR  [data]5015[/data][data]5019[/data] Conclusion  Proton NMR looks good and sample is ready to send for testing, further characterisation still needed. Strings Starting Materials InChI=1S/C13H13NO/c1-10-8-12(9-15)11(2)14(10)13-6-4-3-5-7-13/h3-9H,1-2H3 InChI=1S/C9H8N2O2S/c12-7-3-1-2-6(4-7)10-9-11-8(13)5-14-9/h1-4,12H,5H2,(H,10,11,13) Product InChI=1S/C22H19N3O2S/c1-14-11-16(15(2)25(14)18-8-4-3-5-9-18)12-20-21(27)24-22(28-20)23-17-7-6-10-19(26)13-17/h3-13,26H,1-2H3,(H,23,24,27)/b20-12-
Attached Files
MNR94-1_table.PNG
mnr94-1_1H.pdf
MNR94_scheme.png
mnr94-1.zip
Comments
Re: Synthesis of Near Neighbour Analog MNR94-1 by OSDD Malaria
26th January 2014 @ 22:55
OSM-S-114