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16th January 2013 @ 22:40

one batch black solid, one batch mustard solid: combined: 2.3 g, 11.5 mmol, 64% yield

DMF (5 mL) was stirred under a nitrogen atmosphere in an ice-bath. Phosphoryl chloride (2 mL, 21.7 mmol, 1.2 equiv.) was added and the reaction stirred for 25 minutes. A solution of pyrrole AEW 44-1 (3.1 g, 18.1 mmol, 1 equiv.) in DMF (5 mL) was added dropwise over 5 minutes. The reaction was removed from the ice-bath and allowed to warm to room temperature.

TLC:

NMR:

Hazard and Risk Assessment:

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AEW 49-1.png