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6th November 2017 @ 10:34

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Masses andmeasurements:

4-bromobenzaldehyde - 2.0559g, 11.1mmol

2-chloro-6-hydrazinylpyrazine - 1.6399g, 11.3mmol

Ethanol - 25mL

Procedure:

4-bromobenzaldehyde (2.0559g, 11.1mmol) was dissolved in ethanol (25mL) and stirred in a RBF. Once the solid was dissolved in the ethanol, the 2-chloro-6-hydrazinylpyrazine (1.6399g, 11.3mmol) was slowly added to the stirring reaction mixture. The solution was colourless until the pyrazine was added, which was when the reaction mixture turned an orange foamy mixture. The mixture was stirred for a few hours until TLC analysis (70% pet ether & 30% ethyl acetate) suggested the reaction was complete. The resulting reaction mixture was filtered under vacuo, washed with ethanol and dried over air. The remaining solid product of (E)-2-(2-(4-bromobenzylidene)-6-chloropyrazine (3.2011g, 92.62%) was obtained as an orange powdery solid.

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Attached Files
Step 1 product.jpg
TLC step 1.jpg
Step 1 online lab book.jpg